A Cholesterol-Sensitive Regulator of the Androgen Receptor PRINCIPAL INVESTIGATOR:

CHD8, A Novel Beta-Catenin Associated Chromatin Remodeling Enzyme, Regulates Androgen Receptor Mediated Gene Transcription PRINCIPAL INVESTIGATOR:

AWARD NUMBER: W81XWH-07-1-0224 TITLE: CHD8, A Novel Beta-Catenin Associated Chromatin Remodeling Enzyme, Regulates Androgen Receptor Mediated Gene Transcription PRINCIPAL INVESTIGATOR: Daniel A. Bochar, Ph.D. CONTRACTING ORGANIZATION: University of Michigan Ann Arbor, MI 48109-0606 REPORT DATE: March 2010 TYPE OF REPORT: Final PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort D...

P-91: Androgen Associated Gene Polymorphism(s) in Women with Polycystic Ovary Syndrome from South Indian Population

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting 4-12% of reproductive women worldwide; characterized by chronic anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovaries on ultrasound scan. Ovarian androgen overproduction is the key pathophysiologic feature of PCOS. A number of genes encoding major enzymes of the androgen meta...

AWARD NUMBER: W81XWH-14-1-0480 TITLE: Androgen Receptor Splice Variants and Resistance to Taxane Chemotherapy PRINCIPAL INVESTIGATOR:

Telomerase as an Androgen Receptor-Regulated Target in Selenium Chemoprevention of Prostate Cancer PRINCIPAL INVESTIGATOR:

Does Changing Androgen Receptor Status during Prostate Cancer Development Impact upon Cholesterol Homeostasis?

BACKGROUND Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory element-binding protein 2 (SREBP-2) and liver X receptor (LXR). We previously showed that the androgen receptor, a major player in prosta...